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North of Iran is part of the "Asian esophageal cancer belt", which has some of the highest rates of esophageal cancer (EC) in the world. The earliest reports of this high incidence date back to the early 1970s, when a population-based cancer registry was established as a joint effort between Tehran University and the International Agency for Research on Cancer (IARC). This registry confirmed the high incidence of EC (age-standardized incidence rates of 109/100,000 in men and 175/100,000 in women) in the eastern portion of the Caspian Sea littoral, presently known as Golestan Province. A collaboration was formed in 1995 between Digestive Disease Research Institute of Tehran University of Medical Sciences, National Cancer Institute, and IARC to study EC and the determinants of its high risk in these parts of Iran. This collaboration has since expanded to include other international collaborators, and to answer many more health topics, such as cardiovascular disease, lifestyle, and mortality.

Request Workflow

The workflow of a GEMShare request is presented below.

Workflow begins with a requester submission via the system to a GEMINI admin. The GEMINI
			 admin will perform a preliminary QC, then voters are assigned. If the voters have comments, questions, or votes the Requester
			 will be notified. If any requested corrections are made, the GEMINI admin will review the changes in a preliminary QC before 
			 notifying the voters of the changes. Once a final decision has been made by the voters, IMS admin and GEMINI admin will either
			 release the data and material to the requester or deny the request based on the voters decision.

Acknowledgment

The GEMINI Shared Repository development team would like to acknowledge the role of the National Heart, Lung, and Blood Institute and its BioLINCC Program in the approach used in the development of this website. The GEMINI Shared Repository code was based on the success of the BioLINCC framework, which shares many of the same advanced features and a well-defined yet flexible workflow for request submission and fulfillment.