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Title: Risk of bladder cancer associated with family history of cancer: do low-penetrance polymorphisms account for the increase in risk?
Authors: Murta-Nascimento C,  Silverman DT,  Kogevinas M,  García-Closas M,  Rothman N,  Tardón A,  García-Closas R,  Serra C,  Carrato A,  Villanueva C,  Dosemeci M,  Real FX,  Malats N
Journal: Cancer Epidemiol Biomarkers Prev
Date: 2007 Aug
Branches: OEEB, MEB
PubMed ID: 17684133
PMC ID: not available
Abstract: The relationship between family history of cancer in first-degree relatives and risk of bladder cancer was examined in the Spanish Bladder Cancer Study. Information on family history of cancer was obtained for 1,158 newly diagnosed bladder cancer cases and 1,244 controls included in 18 hospitals between 1998 and 2001. A total of 464 (40.1%) cases and 436 (35.1%) controls reported a family history of cancer in >/=1 relative [odds ratio (OR), 1.32; 95% confidence interval (95% CI), 1.11-1.59]; the OR was 1.23 (95% CI, 1.01-1.50) among those with only one relative affected and 1.67 (95% CI, 1.23-2.29) among those with >/=2 affected relatives (P(trend) = 0.0004). A greater risk of bladder cancer was observed among those diagnosed at age