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Title: The global epidemiology of hepatocellular carcinoma: present and future.
Authors: McGlynn KA,  London WT
Journal: Clin Liver Dis
Date: 2011 May
Branches: MEB
PubMed ID: 21689610
PMC ID: PMC4141529
Abstract: The global risk of hepatocellular carcinoma (HCC) has been largely driven by hepatitis B virus (HBV) infection for the past century, along with hepatitis C virus (HCV), aflatoxin, excessive alcohol consumption, and obesity/diabetes. The dominant effect of HBV on global HCC risk should decline as the population vaccinated against HBV grows older. Infection with HCV is also expected to decline. Projections of HCV-related HCC rates remaining high for another 30 years may be overly pessimistic. Alcohol may be less of a factor in HCC in coming years. However, obesity and diabetes may become even more important risk factors for HCC.