Skip to Content
Discovering the causes of cancer and the means of prevention

Publications Search - Abstract View

Title: Common variants in ZNF365 are associated with both mammographic density and breast cancer risk.
Authors: Lindström S,  Vachon CM,  Li J,  Varghese J,  Thompson D,  Warren R,  Brown J,  Leyland J,  Audley T,  Wareham NJ,  Loos RJ,  Paterson AD,  Rommens J,  Waggott D,  Martin LJ,  Scott CG,  Pankratz VS,  Hankinson SE,  Hazra A,  Hunter DJ,  Hopper JL,  Southey MC,  Chanock SJ,  Silva Idos S,  Liu J,  Eriksson L,  Couch FJ,  Stone J,  Apicella C,  Czene K,  Kraft P,  Hall P,  Easton DF,  Boyd NF,  Tamimi RM
Journal: Nat Genet
Date: 2011 Mar
Branches: CGR, LTG
PubMed ID: 21278746
PMC ID: PMC3076615
Abstract: High-percent mammographic density adjusted for age and body mass index is one of the strongest risk factors for breast cancer. We conducted a meta analysis of five genome-wide association studies of percent mammographic density and report an association with rs10995190 in ZNF365 (combined P = 9.6 × 10(-10)). Common variants in ZNF365 have also recently been associated with susceptibility to breast cancer.