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Title: HPV-associated Oropharyngeal Cancers--Are They Preventable?
Authors: Kreimer AR,  Chaturvedi AK
Journal: Cancer Prev Res (Phila)
Date: 2011 Sep
Branches: IIB
PubMed ID: 21893495
PMC ID: PMC3326607
Abstract: It is not known whether a human papillomavirus (HPV)-induced oropharyngeal precancerous lesion could be identified by screening with a pap test equivalent or whether one even exists. In this issue of the journal (beginning on page 1378), Fakhry and colleagues report their results showing that cytologic evaluation of the oropharynx, although useful in detecting invasive oropharyngeal cancers, may have limited utility as a screening modality for detecting precancer. These findings argue against the potential for secondary prevention of HPV-associated oropharyngeal cancers through screening for and preventing the progression of precancer and highlight the opportunity for primary prevention through prophylactic HPV vaccination, if proven efficacious and cost-effective.