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Title: Invited commentary: from genome-wide association studies to gene-environment-wide interaction studies--challenges and opportunities.
Authors: Khoury MJ,  Wacholder S
Journal: Am J Epidemiol
Date: 2009 Jan 15
Branches: BB
PubMed ID: 19022826
PMC ID: PMC2727257
Abstract: The recent success of genome-wide association studies in finding susceptibility genes for many common diseases presents tremendous opportunities for epidemiologic studies of environmental risk factors. Analysis of gene-environment interactions, included in only a small fraction of epidemiologic studies until now, will begin to accelerate as investigators integrate analyses of genome-wide variation and environmental factors. Nevertheless, considerable methodological challenges are involved in the design and analysis of gene-environment interaction studies. The authors review these issues in the context of evolving methods for assessing interactions and discuss how the current agnostic approach to interrogating the human genome for genetic risk factors could be extended into a similar approach to gene-environment-wide interaction studies of disease occurrence in human populations.