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Title: Cohort studies for characterizing measured genes.
Authors: Langholz B,  Rothman N,  Wacholder S,  Thomas DC
Journal: J Natl Cancer Inst Monogr
Date: 1999
Branches: BB, OEEB
PubMed ID: 10854484
PMC ID: not available
Abstract: We describe the advantages of using established cohort studies that have collected blood samples to investigate the role of genes in the etiology of cancer. These studies include the cost-efficiency and reliability of nested case-control substudies from the cohort for exploration of gene-disease associations and gene-environment interactions as well as gene penetrance. Also, the cohort may serve as a well-defined "mini-population" from which to study population stratification and molecular markers of ethnicity. We conclude that cohort studies can play a significant role in assessing the role of genetic markers for common tumors or multiple cancer sites.