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Title: One-carbon metabolism dietary factors and distal gastric cancer risk in chinese women.
Authors: Kweon SS,  Shu XO,  Xiang Y,  Yang G,  Ji BT,  Li H,  Gao YT,  Zheng W,  Shrubsole MJ
Journal: Cancer Epidemiol Biomarkers Prev
Date: 2014 Jul
Branches: OEEB
PubMed ID: 24789845
PMC ID: PMC4082459
Abstract: BACKGROUND: Previous studies on the association between one-carbon dietary factors and gastric cancer risk have been inconsistent. METHODS: We investigated this association using data from a prospective study, the Shanghai Women's Health Study (1997-2010), including 323 distal gastric cancer cases identified from 73,009 Chinese women. HRs and 95% confidence intervals (CI) were estimated using Cox proportional hazard regression after adjusting for confounders. RESULTS: Overall, no statistically significant association of gastric cancer was observed with dietary intake of folate, methionine, or B vitamins. However, when stratified by menopausal status, higher intake of riboflavin was associated with decreased gastric cancer risk in premenopausal women with HR of 0.35 (95% CI, 0.17-0.73), 0.48 (0.24-0.97), 0.28 (0.12-0.65), and 0.23 (0.07-0.91), respectively, for the quintiles 2 to 5 intake groups compared with the lowest quintile intake (P for trend = 0.02). Among premenopausal women, highest intake of folate was associated with increased gastric cancer risk (HR, 2.62; 95% CI, 1.04-6.59). There were no statistically significant associations observed among postmenopausal women. CONCLUSIONS: These results suggest that dietary factors involved in one-carbon metabolism are associated with gastric cancer risk among premenopausal women. IMPACT: Riboflavin may be a protective factor and folate may be a risk factor for premenopausal gastric cancer.