Skip to Content
Discovering the causes of cancer and the means of prevention

Publications Search - Abstract View

Title: MICA and recovery from hepatitis C virus and hepatitis B virus infections.
Authors: Karacki PS,  Gao X,  Thio CL,  Thomas DL,  Goedert JJ,  Vlahov D,  Kaslow RA,  Strathdee S,  Hilgartner MW,  O'Brien SJ,  Carrington M
Journal: Genes Immun
Date: 2004 Jun
Branches: IIB
PubMed ID: 15029237
PMC ID: not available
Abstract: The polymorphic MHC class I chain-related A (MICA) gene encodes a ligand that has different binding affinities for the NKG2D activating receptor of CD8+ T cells and natural killer (NK) cells. We hypothesized that MICA heterogeneity would affect recovery from hepatitis C virus (HCV) and hepatitis B virus (HBV) infections. To test the hypothesis, we initially typed known MICA polymorphisms for 228 persons who cleared HCV infection and 442 persons with persistent hepatitis C matched on other factors affecting viral persistence. Although MICA(*)015 was detected more than two-fold more often in persons with viral clearance (odds ratio 0.36, 95% confidence interval=0.19, 0.80), it occurred in fewer than 5% of the study population. In a similar analysis of 442 persons with chronic hepatitis B and 768 matched controls who recovered, MICA(*)015 was detected in 2.0% of persons with chronic hepatitis B and only 0.9% of controls. No significant associations were detected with other MICA polymorphisms. While further investigation may reveal a structural basis of the MICA(*)015 associations, these data provide little support for the hypothesis that differential distribution of MICA alleles substantially affects recovery from HCV and HBV infections.