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Title: The effect on melanoma risk of genes previously associated with telomere length.
Authors: Iles MM,  Bishop DT,  Taylor JC,  Hayward NK,  Brossard M,  Cust AE,  Dunning AM,  Lee JE,  Moses EK,  Akslen LA,  AMFS Investigators,  Andresen PA,  Avril MF,  Azizi E,  Scarrà GB,  Brown KM,  Dębniak T,  Elder DE,  Friedman E,  Ghiorzo P,  Gillanders EM,  Goldstein AM,  Gruis NA,  Hansson J,  Harland M,  Helsing P,  Hočevar M,  Höiom V,  IBD investigators,  Ingvar C,  Kanetsky PA,  Landi MT,  Lang J,  Lathrop GM,  Lubiński J,  Mackie RM,  Martin NG,  Molven A,  Montgomery GW,  Novaković S,  Olsson H,  Puig S,  Puig-Butille JA,  QMEGA and QTWIN Investigators,  Radford-Smith GL,  Randerson-Moor J,  SDH Study Group,  van der Stoep N,  van Doorn R,  Whiteman DC,  MacGregor S,  Pooley KA,  Ward SV,  Mann GJ,  Amos CI,  Pharoah PD,  Demenais F,  Law MH,  Newton Bishop JA,  Barrett JH,  GenoMEL Consortium
Journal: J Natl Cancer Inst
Date: 2014 Oct
Branches: ITEB, LTG
PubMed ID: 25231748
PMC ID: PMC4196080
Abstract: Telomere length has been associated with risk of many cancers, but results are inconsistent. Seven single nucleotide polymorphisms (SNPs) previously associated with mean leukocyte telomere length were either genotyped or well-imputed in 11108 case patients and 13933 control patients from Europe, Israel, the United States and Australia, four of the seven SNPs reached a P value under .05 (two-sided). A genetic score that predicts telomere length, derived from these seven SNPs, is strongly associated (P = 8.92x10(-9), two-sided) with melanoma risk. This demonstrates that the previously observed association between longer telomere length and increased melanoma risk is not attributable to confounding via shared environmental effects (such as ultraviolet exposure) or reverse causality. We provide the first proof that multiple germline genetic determinants of telomere length influence cancer risk.