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Title: Virus markers associated with vertical transmission of human T lymphotropic virus type 1 in Jamaica.
Authors: Hisada M,  Maloney EM,  Sawada T,  Miley WJ,  Palmer P,  Hanchard B,  Goedert JJ,  Manns A
Journal: Clin Infect Dis
Date: 2002 Jun 15
Branches: IIB
PubMed ID: 12032888
PMC ID: not available
Abstract: In a prospective study involving 150 mothers and their offspring in Jamaica, we examined maternal viral factors associated with the risk of transmission of human T lymphotropic virus type 1 (HTLV-1). Overall, the incidence of HTLV-1 infection among children was 8.3 occurrences per 1000 person-months. A higher maternal provirus level (odds ratio [OR], 1.9 per quartile) and a higher HTLV-1 antibody titer (OR, 2.2 per quartile) were independently associated with transmission to children, whereas the presence of anti-Tax antibody was not. Higher maternal antibody titers also were associated with older age at infection among children who were breast-fed for