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Title: Meta-analysis of genome-wide association studies of adult height in East Asians identifies 17 novel loci.
Authors: He M,  Xu M,  Zhang B,  Liang J,  Chen P,  Lee JY,  Johnson TA,  Li H,  Yang X,  Dai J,  Liang L,  Gui L,  Qi Q,  Huang J,  Li Y,  Adair LS,  Aung T,  Cai Q,  Cheng CY,  Cho MC,  Cho YS,  Chu M,  Cui B,  Gao YT,  Go MJ,  Gu D,  Gu W,  Guo H,  Hao Y,  Hong J,  Hu Z,  Hu Y,  Huang J,  Hwang JY,  Ikram MK,  Jin G,  Kang DH,  Khor CC,  Kim BJ,  Kim HT,  Kubo M,  Lee J,  Lee J,  Lee NR,  Li R,  Li J,  Liu J,  Longe J,  Lu W,  Lu X,  Miao X,  Okada Y,  Ong RT,  Qiu G,  Seielstad M,  Sim X,  Song H,  Takeuchi F,  Tanaka T,  Taylor PR,  Wang L,  Wang W,  Wang Y,  Wu C,  Wu Y,  Xiang YB,  Yamamoto K,  Yang H,  Liao M,  Yokota M,  Young T,  Zhang X,  Kato N,  Wang QK,  Zheng W,  Hu FB,  Lin D,  Shen H,  Teo YY,  Mo Z,  Wong TY,  Lin X,  Mohlke KL,  Ning G,  Tsunoda T,  Han BG,  Shu XO,  Tai ES,  Wu T,  Qi L
Journal: Hum Mol Genet
Date: 2015 Mar 15
Branches: ITEB
PubMed ID: 25429064
PMC ID: PMC4351379
Abstract: Human height is associated with risk of multiple diseases and is profoundly determined by an individual's genetic makeup and shows a high degree of ethnic heterogeneity. Large-scale genome-wide association (GWA) analyses of adult height in Europeans have identified nearly 180 genetic loci. A recent study showed high replicability of results from Europeans-based GWA studies in Asians; however, population-specific loci may exist due to distinct linkage disequilibrium patterns. We carried out a GWA meta-analysis in 93 926 individuals from East Asia. We identified 98 loci, including 17 novel and 81 previously reported loci, associated with height at P < 5 10(-8), together explaining 8.89% of phenotypic variance. Among the newly identified variants, 10 are commonly distributed (minor allele frequency, MAF > 5%) in Europeans, with comparable frequencies with in Asians, and 7 single-nucleotide polymorphisms are with low frequency (MAF < 5%) in Europeans. In addition, our data suggest that novel biological pathway such as the protein tyrosine phosphatase family is involved in regulation of height. The findings from this study considerably expand our knowledge of the genetic architecture of human height in Asians.