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Title: Analysis of exposure-time-response relationships using a spline weight function.
Authors: Hauptmann M,  Wellmann J,  Lubin JH,  Rosenberg PS,  Kreienbrock L
Journal: Biometrics
Date: 2000 Dec
Branches: BB
PubMed ID: 11129467
PMC ID: not available
Abstract: To examine the time-dependent effects of exposure histories on disease, we estimate a weight function within a generalized linear model. The shape of the weight function, which is modeled as a cubic B-spline, gives information about the impact of exposure increments at different times on disease risk. The method is evaluated in a simulation study and is applied to data on smoking histories and lung cancer from a recent case-control study in Germany.