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Title: Familial clustering of classic Kaposi sarcoma.
Authors: Guttman-Yassky E,  Cohen A,  Kra-Oz Z,  Friedman-Birnbaum R,  Sprecher E,  Zaltzman N,  Friedman E,  Silbermann M,  Rubin D,  Linn S,  Whitby D,  Gideoni O,  Pollack S,  Bergman R,  Sarid R
Journal: J Infect Dis
Date: 2004 Jun 1
Branches: IIB
PubMed ID: 15143469
PMC ID: not available
Abstract: It is widely accepted that there is a causal association between Kaposi sarcoma-associated herpesvirus (KSHV) and Kaposi sarcoma (KS). However, the majority of individuals infected with KSHV never develop KS. Here, we present a unique familial case of classic KS, in which the disease occurs in 4 siblings who have no recognized underlying immunodeficiency. We examine risk factors that could play a role in this condition, including KSHV infection, KSHV DNA load, genetic variants of KSHV, infection with additional viruses, interleukin-6-promoter polymorphism, and HLA genotype. We hypothesize that a genetic susceptibility to KS, in combination with KSHV infection, may play an important role in the presented familial case.