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Title: Risk of human T-lymphotropic virus type I-associated diseases in Jamaica with common HLA types.
Authors: Goedert JJ,  Li HC,  Gao XJ,  Chatterjee N,  Sonoda S,  Biggar RJ,  Cranston B,  Kim N,  Carrington M,  Morgan O,  Hanchard B,  Hisada M
Journal: Int J Cancer
Date: 2007 Sep 1
Branches: IIB, BB
PubMed ID: 17437273
PMC ID: not available
Abstract: Human T-lymphotropic virus-I (HTLV-I) causes adult T-cell leukemia/lymphoma (ATL) and HTLV-associated myelopathy/tropical spastic paraparesis (HAM/TSP). We postulated a higher disease risk for people with common human leukocyte antigen (HLA) types, due to a narrower immune response against viral or neoplastic antigens, compared to people with uncommon types. HLA class-I (A,B) and class-II (DRB1, DQB1) allele and haplotype frequencies in 56 ATL patients, 59 HAM/TSP patients and 190 population-based, asymptomatic HTLV-I-infected carriers were compared by logistic regression overall (score test) and with odds ratios (ORs) for common types (prevalence >50% of asymptomatic carriers) and by prevalence quartile. HTLV-I proviral load between asymptomatic carriers with common versus uncommon types was compared by t-test. ATL differed from asymptomatic carriers in overall DQB1 allele and class-I haplotype frequencies (p