Skip to Content
Discovering the causes of cancer and the means of prevention

Publications Search - Abstract View

Title: Dysplastic nevi and melanoma.
Authors: Goldstein AM,  Tucker MA
Journal: Cancer Epidemiol Biomarkers Prev
Date: 2013 Apr
Branches: ITEB, HGP, OD
PubMed ID: 23549396
PMC ID: PMC3616416
Abstract: Dysplastic nevi are described as being on a continuum between common acquired nevi and melanoma because they are morphologically and biologically intermediate between these 2 entities. Since initially being reported as histologic lesions observed in melanoma-prone families, there has been considerable debate about the definition of dysplastic nevi, the histologic and clinical criteria used to define them, and their biologic importance. Their role as precursor lesions for melanoma is not their primary role in their relationship to melanoma because of the rarity of transformation of any individual nevus to a melanoma. Although there is still no single, universally agreed upon histologic or clinical definition or even name for these nevi, dysplastic nevi should be considered important because of their association with an increased risk for melanoma.