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Title: Circulating 25-hydroxyvitamin D and risk of kidney cancer: Cohort Consortium Vitamin D Pooling Project of Rarer Cancers.
Authors: Gallicchio L,  Moore LE,  Stevens VL,  Ahn J,  Albanes D,  Hartmuller V,  Setiawan VW,  Helzlsouer KJ,  Yang G,  Xiang YB,  Shu XO,  Snyder K,  Weinstein SJ,  Yu K,  Zeleniuch-Jacquotte A,  Zheng W,  Cai Q,  Campbell DS,  Chen Y,  Chow WH,  Horst RL,  Kolonel LN,  McCullough ML,  Purdue MP,  Koenig KL
Journal: Am J Epidemiol
Date: 2010 Jul 1
Branches: OEEB, MEB, BB, IIB
PubMed ID: 20562187
PMC ID: PMC2892538
Abstract: Although the kidney is a major organ for vitamin D metabolism, activity, and calcium-related homeostasis, little is known about whether this nutrient plays a role in the development or the inhibition of kidney cancer. To address this gap in knowledge, the authors examined the association between circulating 25-hydroxyvitamin D (25(OH)D) and kidney cancer within a large, nested case-control study developed as part of the Cohort Consortium Vitamin D Pooling Project of Rarer Cancers. Concentrations of 25(OH)D were measured from 775 kidney cancer cases and 775 age-, sex-, race-, and season-matched controls from 8 prospective cohort studies. Overall, neither low nor high concentrations of circulating 25(OH)D were significantly associated with kidney cancer risk. Although the data showed a statistically significant decreased risk for females (odds ratio = 0.31, 95% confidence interval: 0.12, 0.85) with 25(OH)D concentrations of > or =75 nmol/L, the linear trend was not statistically significant and the number of cases in this category was small (n = 14). The findings from this consortium-based study do not support the hypothesis that vitamin D is inversely associated with the risk of kidney cancer overall or with renal cell carcinoma specifically.