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Title: Detecting gene-environment interactions using a case-control design.
Authors: Goldstein AM,  Falk RT,  Korczak JF,  Lubin JH
Journal: Genet Epidemiol
Date: 1997
Branches: BB, MEB, ITEB
PubMed ID: 9433628
PMC ID: not available
Abstract: We assessed the sample size required for detecting gene-environment (G x E) interactions in a case-control study of complex diseases. The results suggest that large numbers of cases and controls will be required to detect G x E interaction for some odds ratio and exposure frequency combinations. These and other results suggest that alternative study designs may be needed to detect G x E interaction particularly with rare genes or uncommon environmental exposures.