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Title: Associations of body mass index, smoking, and alcohol consumption with prostate cancer mortality in the Asia Cohort Consortium.
Authors: Fowke JH,  McLerran DF,  Gupta PC,  He J,  Shu XO,  Ramadas K,  Tsugane S,  Inoue M,  Tamakoshi A,  Koh WP,  Nishino Y,  Tsuji I,  Ozasa K,  Yuan JM,  Tanaka H,  Ahn YO,  Chen CJ,  Sugawara Y,  Yoo KY,  Ahsan H,  Pan WH,  Pednekar M,  Gu D,  Xiang YB,  Sauvaget C,  Sawada N,  Wang R,  Kakizaki M,  Tomata Y,  Ohishi W,  Butler LM,  Oze I,  Kim DH,  You SL,  Park SK,  Parvez F,  Chuang SY,  Chen Y,  Lee JE,  Grant E,  Rolland B,  Thornquist M,  Feng Z,  Zheng W,  Boffetta P,  Sinha R,  Kang D,  Potter JD
Journal: Am J Epidemiol
Date: 2015 Sep 1
Branches: MEB, OEEB
PubMed ID: 26243736
PMC ID: PMC4643758
Abstract: Many potentially modifiable risk factors for prostate cancer are also associated with prostate cancer screening, which may induce a bias in epidemiologic studies. We investigated the associations of body mass index (weight (kg)/height (m)(2)), smoking, and alcohol consumption with risk of fatal prostate cancer in Asian countries where prostate cancer screening is not widely utilized. Analysis included 18 prospective cohort studies conducted during 1963-2006 across 6 countries in southern and eastern Asia that are part of the Asia Cohort Consortium. Body mass index, smoking, and alcohol intake were determined by questionnaire at baseline, and cause of death was ascertained through death certificates. Analysis included 522,736 men aged 54 years, on average, at baseline. During 4.8 million person-years of follow-up, there were 634 prostate cancer deaths (367 prostate cancer deaths across the 11 cohorts with alcohol data). In Cox proportional hazards analyses of all cohorts in the Asia Cohort Consortium, prostate cancer mortality was not significantly associated with obesity (body mass index >25: hazard ratio (HR) = 1.08, 95% confidence interval (CI): 0.85, 1.36), ever smoking (HR = 1.00, 95% CI: 0.84, 1.21), or heavy alcohol intake (HR = 1.00, 95% CI: 0.74, 1.35). Differences in prostate cancer screening and detection probably contribute to differences in the association of obesity, smoking, or alcohol intake with prostate cancer risk and mortality between Asian and Western populations and thus require further investigation.