Skip to Content
Discovering the causes of cancer and the means of prevention

Publications Search - Abstract View

Title: Cancer risk among lung transplant recipients with cystic fibrosis.
Authors: Fink AK,  Yanik EL,  Marshall BC,  Wilschanski M,  Lynch CF,  Austin AA,  Copeland G,  Safaeian M,  Engels EA
Journal: J Cyst Fibros
Date: 2017 Jan
Branches: IIB
PubMed ID: 27539828
PMC ID: not available
Abstract: BACKGROUND: Previous studies demonstrated increased digestive tract cancers among individuals with cystic fibrosis (CF), particularly among lung transplant recipients. We describe cancer incidence among CF and non-CF lung recipients. METHODS: We used data from the US transplant registry and 16 cancer registries. Standardized incidence ratios (SIRs) compared cancer incidence to the general population, and competing risk methods were used for the cumulative incidence of colorectal cancer. RESULTS: We evaluated 10,179 lung recipients (1681 with CF). Risk was more strongly increased in CF recipients than non-CF recipients for overall cancer (SIR 9.9 vs. 2.7) and multiple cancers including colorectal cancer (24.2 vs. 1.7), esophageal cancer (56.3 vs. 1.3), and non-Hodgkin lymphoma (61.8 vs. 9.4). At five years post-transplant, colorectal cancer was diagnosed in 0.3% of CF recipients aged <50 at transplant and 6.4% aged ≥50. CONCLUSIONS: CF recipients have increased risk for colorectal cancer, suggesting a need for enhanced screening.