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Title: Trans-ethnic genome-wide association study of colorectal cancer identifies a new susceptibility locus in VTI1A.
Authors: Wang H,  Burnett T,  Kono S,  Haiman CA,  Iwasaki M,  Wilkens LR,  Loo LW,  Van Den Berg D,  Kolonel LN,  Henderson BE,  Keku TO,  Sandler RS,  Signorello LB,  Blot WJ,  Newcomb PA,  Pande M,  Amos CI,  West DW,  Bézieau S,  Berndt SI,  Zanke BW,  Hsu L,  Genetics and Epidemiology of Colorectal Cancer Consortium (GECCO),  Lindor NM,  Haile RW,  Hopper JL,  Jenkins MA,  Gallinger S,  Casey G,  Colon Cancer Family Registry (CCFR),  Stenzel SL,  Schumacher FR,  Peters U,  Gruber SB,  Colorectal Transdisciplinary Study (CORECT),  Tsugane S,  Stram DO,  Le Marchand L
Journal: Nat Commun
Date: 2014 Aug 8
Branches: LTG, OD, OEEB
PubMed ID: 25105248
PMC ID: PMC4180879
Abstract: The genetic basis of sporadic colorectal cancer (CRC) is not well explained by known risk polymorphisms. Here we perform a meta-analysis of two genome-wide association studies in 2,627 cases and 3,797 controls of Japanese ancestry and 1,894 cases and 4,703 controls of African ancestry, to identify genetic variants that contribute to CRC susceptibility. We replicate genome-wide statistically significant associations (P<5 × 10(-8)) in 16,823 cases and 18,211 controls of European ancestry. This study reveals a new pan-ethnic CRC risk locus at 10q25 (rs12241008, intronic to VTI1A; P=1.4 × 10(-9)), providing additional insight into the aetiology of CRC and highlighting the value of association mapping in diverse populations.