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Title: Human Papillomavirus (HPV) L1 Serum Antibodies and the Risk of Subsequent Oral HPV Acquisition in Men: The HIM Study.
Authors: Pierce Campbell CM,  Viscidi RP,  Torres BN,  Lin HY,  Fulp W,  Abrahamsen M,  Lazcano-Ponce E,  Villa LL,  Kreimer AR,  Giuliano AR
Journal: J Infect Dis
Date: 2016 Jul 1
Branches: IIB
PubMed ID: 26931445
PMC ID: PMC4907411
Abstract: The role of antibody-mediated immunity in preventing newly acquired oral human papillomavirus (HPV) is not well understood. Among 1618 men participating in the HPV Infection in Men (HIM) Study, we evaluated oral rinses for HPV DNA and baseline sera for HPV-6, -11, -16, and -18 L1 antibodies. Thirty percent of men (486) were seropositive for ≥1 HPV type, and 25 men developed incident oral HPV infection (HPV-6 was detected in 7, HPV-11 in 0, HPV-16 in 17, and HPV-18 in 1). Cox models revealed that men with circulating antibodies to HPV-6, -11, -16, or -18 were not less likely to acquire type-specific oral HPV than men without antibodies (hazard ratio for the risk of acquiring HPV-6, -11, -16, or -18, 1.63; 95% confidence interval, .56-4.76).