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Title: Use of selenium concentration in whole blood, serum, toenails, or urine as a surrogate measure of selenium intake.
Authors: Longnecker MP,  Stram DO,  Taylor PR,  Levander OA,  Howe M,  Veillon C,  McAdam PA,  Patterson KY,  Holden JM,  Morris JS,  Swanson CA,  Willett WC
Journal: Epidemiology
Date: 1996 Jul
Branches: EBP, GEB
PubMed ID: 8793364
PMC ID: not available
Abstract: We examined the validity of using the selenium level in a single biological specimen as a surrogate measure of usual intake. We used data from 77 free-living adults from South Dakota and Wyoming. Subjects provided multiple 1-day duplicate-plate food composites, repeated specimens of blood and toenails, and 24-hour urine collections. We developed a statistical calibration method that incorporated measurement error correction to analyze the data. The Pearson correlation coefficients between selenium intake and a single selenium status measure, after deattenuation to adjust for the effect of within-person variation in intake, were: 0.78 for whole blood, 0.74 for serum, 0.67 for toenails, and 0.86 for urine. We present formulas to estimate the intake of individuals, based on selenium levels in a single specimen of blood, toenails, or urine. In these data, the concentration of selenium in a single specimen of whole blood, serum, or toenails served reasonably well as a measure for ranking subjects according to long-term selenium intake but provided only a rough estimate of intake for each subject.