Skip to Content
Discovering the causes of cancer and the means of prevention

Publications Search - Abstract View

Title: A prospective study of human papillomavirus (HPV) type 16 DNA detection by polymerase chain reaction and its association with acquisition and persistence of other HPV types.
Authors: Liaw KL,  Hildesheim A,  Burk RD,  Gravitt P,  Wacholder S,  Manos MM,  Scott DR,  Sherman ME,  Kurman RJ,  Glass AG,  Anderson SM,  Schiffman M
Journal: J Infect Dis
Date: 2001 Jan 1
Branches: BB, MEB
PubMed ID: 11087198
PMC ID: not available
Abstract: Human papillomavirus (HPV)-16 causes about half the cases of cervical cancer worldwide and is the focus of HPV vaccine development efforts. Systematic data are lacking as to whether the prevention of HPV-16 could affect the equilibrium of infection with other HPV types and thus alter the predicted impact of vaccination on the occurrence of cervical neoplasia. Therefore, the associations of HPV-16 detection with subsequent acquisition of other HPV types and with the persistence of concomitantly detected HPV types were examined prospectively among 1124 initially cytologically normal women. Preexisting HPV-16 was generally associated with an increased risk for subsequent acquisition of other types. HPV-16 did not affect the persistence of concomitant infections, regardless of type. These findings suggest that the prevention or removal of HPV-16 is not likely to promote the risk of infection with other types, a theoretical concern with current vaccination efforts.