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Title: Circulating 25-hydroxyvitamin D and risk of pancreatic cancer: Cohort Consortium Vitamin D Pooling Project of Rarer Cancers.
Authors: Stolzenberg-Solomon RZ,  Jacobs EJ,  Arslan AA,  Qi D,  Patel AV,  Helzlsouer KJ,  Weinstein SJ,  McCullough ML,  Purdue MP,  Shu XO,  Snyder K,  Virtamo J,  Wilkins LR,  Yu K,  Zeleniuch-Jacquotte A,  Zheng W,  Albanes D,  Cai Q,  Harvey C,  Hayes R,  Clipp S,  Horst RL,  Irish L,  Koenig K,  Le Marchand L,  Kolonel LN
Journal: Am J Epidemiol
Date: 2010 Jul 1
Branches: OEEB, NEB, BB, IIB
PubMed ID: 20562185
PMC ID: PMC2892543
Abstract: Results from epidemiologic studies examining pancreatic cancer risk and vitamin D intake or 25-hydroxyvitamin D (25(OH)D) concentrations (the best indicator of vitamin D derived from diet and sun) have been inconsistent. Therefore, the authors conducted a pooled nested case-control study of participants from 8 cohorts within the Cohort Consortium Vitamin D Pooling Project of Rarer Cancers (VDPP) (1974-2006) to evaluate whether prediagnostic circulating 25(OH)D concentrations were associated with the development of pancreatic cancer. In total, 952 incident pancreatic adenocarcinoma cases occurred among participants (median follow-up, 6.5 years). Controls (n = 1,333) were matched to each case by cohort, age, sex, race/ethnicity, date of blood draw, and follow-up time. Conditional logistic regression analysis was used to calculate smoking-, body mass index-, and diabetes-adjusted odds ratios and 95% confidence intervals for pancreatic cancer. Clinically relevant 25(OH)D cutpoints were compared with a referent category of 50-<75 nmol/L. No significant associations were observed for participants with lower 25(OH)D status. However, a high 25(OH)D concentration (> or =100 nmol/L) was associated with a statistically significant 2-fold increase in pancreatic cancer risk overall (odds ratio = 2.12, 95% confidence interval: 1.23, 3.64). Given this result, recommendations to increase vitamin D concentrations in healthy persons for the prevention of cancer should be carefully considered.