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Title: A weighted test using both extreme discordant and concordant sib pairs for detecting linkage.
Authors: Li Z,  Gastwirth JL
Journal: Genet Epidemiol
Date: 2001 Jan
Branches: BB
PubMed ID: 11119295
PMC ID: not available
Abstract: Statistical procedures using extremely discordant and concordant sib-pairs have been developed for mapping quantitative trait loci in humans. To improve the power of the existing methods, test statistics placing greater weight on the more discordant or more concordant pairs are proposed. Because the optimum choice of weights would depend on the underlying genetic model, which is not usually known, a test with simple weights is suggested. This test is shown to have greater power than the currently available ones for a variety of genetic models.