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||SERUM VITAMIN D AND RISK OF PANCREATIC CANCER in: Abstracts of the 41st Annual Meeting of the Society for Epidemiologic Research
||Stolzenberg-Solomon RZ, Horst R, Hayes RB, Silverman DT
||Am J Epidemiol
||2008 Jun 1
||Experimental evidence suggests vitamin D has anticarcinogenic properties,however, a recent nested-case control study conducted in a population ofmale smokers showed that higher 25(OH) vitamin D-the major circulatingvitamin D metabolite and is also considered the best indicator of vitamin Dstatus as determined by the sun and diet-was associated with a significant3-fold increased risk for pancreatic cancer. We conducted a nested casecontrolstudy in the PLCO cohort of men and women 55-74 years of age atbaseline, to test whether pre-diagnostic serum 25(OH) vitamin D concentrationswere associated with pancreatic cancer risk. One hundred eightyfour incident cases of adenocarcinoma of the pancreas that occurred between1994 and 2006 (follow-up to 11.7 years, median 5.4 years) werematched by age, race, sex, and date of blood draw to 368 controls whowere alive at the time the case was diagnosed. Smoking and body massindex adjusted odds ratios (ORs) and 95% confidence intervals (CI) werecalculated using conditional logistic regression. Higher vitamin D concentrationswere not significantly associated with pancreatic cancer (highest vs.lowest quintile, >82.3 vs. < 45.9 nmol/L: OR = 1.45, 95% CI 0.66-3.15,p-trend = 0.49). Our results do not support the hypothesis that highervitamin D status plays a protective role in pancreatic cancer carcinogenesis.