Publications Search - Abstract View
||Revisiting tissue specificity of germline cancer predisposing mutations.
||Maris JM, Knudson AG
||Nat Rev Cancer
||Heritable germline mutations in major cancer genes generally lead to a restricted pattern of tissue-specific malignancies, yet many of the same mutations frequently occur somatically in a broad range of spontaneous neoplasms affecting different organs. Might this reflect a difference in tumorigenesis in children and adults?