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||Multiple myeloma and occupation: a pooled analysis by the International Multiple Myeloma Consortium.
||Perrotta C, Kleefeld S, Staines A, Tewari P, De Roos AJ, Baris D, Birmann B, Chiu B, Cozen W, Becker N, Foretova L, Maynadié M, Nieters A, de Sanjosé S, Miligi L, Seniori Costantini A, Purdue M, Spinelli J, Cocco P
||OBJECTIVE: We investigated occupational risk of multiple myeloma (MM) in a pooled analysis of five international case-control studies. METHODS: We calculated the odds ratio and its 95% confidence interval for selected occupations with unconditional regression analysis in 1959 MM cases and 6192 controls, by pooling study-specific risks using random-effects meta-analysis. Exposure to organic solvents was assessed with a job-exposure matrix (JEM). RESULTS: Gardeners and nursery workers combined, most likely exposed to pesticides, showed a 50% increase in risk (OR = 1.50, 95% CI 0.9-2.3), while other farming jobs did not. Metal processors (OR = 1.55, 95% CI 0.9-2.3), female cleaners (OR = 1.32, 95% CI 1.0-1.8), and high level exposure to organic solvents (OR = 1.38, 95% CI 0.96-1.8) also showed moderately increased risks. CONCLUSIONS: Additional case-control studies of MM aetiology are warranted to further investigate the nature of the repeatedly reported increase in MM risk in several occupational groups.