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Title: Efficient interval estimation of a ratio of marginal probabilities in matched-pair data: non-iterative method.
Authors: Nam JM
Journal: Stat Med
Date: 2009 Oct 15
Branches: BB
PubMed ID: 19691020
PMC ID: PMC2785096
Abstract: Matched-pair designs have been commonly employed in diagnostic, epidemiologic and laboratory studies. For estimation of a ratio of two marginal probabilities in matched-pair data, a Wald-type logarithmic method is computationally simple, but an actual coverage rate is known to be smaller than a nominal one and a length of the confidence interval is shorter than it should be. The Fieller-type method based on constrained maximum likelihood (CML) estimators possesses asymptotically optimum statistical properties and a coverage rate is close to a nominal one. However, hitherto the limits have been obtained by numerical iterations. In this paper, we derive the efficient confidence limits based on CML as analytical solutions of a quartic equation and present the confidence limits in a closed form.