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Title: Evidence suggesting the role of specific genetic factors in cigarette smoking.
Authors: Lerman C,  Caporaso NE,  Audrain J,  Main D,  Bowman ED,  Lockshin B,  Boyd NR,  Shields PG
Journal: Health Psychol
Date: 1999 Jan
Branches: GEB
PubMed ID: 9925041
PMC ID: not available
Abstract: Twin studies suggest that propensity to smoke and ability to quit smoking are influenced by genetic factors. As a means of investigating the risk of smoking associated with genetic polymorphisms in the dopamine transporter (SLC6A3) and the D2 dopamine receptor (DRD2) genes, a case-control study of 289 smokers and 233 nonsmoking controls and a case series analysis of smokers were conducted. A significant effect for SLC6A3 and a significant gene-gene interaction were found in a logistic regression model, indicating that individuals with SLC6A3-9 genotypes were significantly less likely to be smokers, especially if they also had DRD2-A2 genotypes. Smokers with SLC6A3-9 genotypes were also significantly less likely to have started smoking before 16 years of age and had prior smoking histories indicating a longer period of prior smoking cessation. This study provides preliminary evidence that the SLC6A3 gene may influence smoking initiation and nicotine dependence.