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Title: Adiposity in relation to colorectal adenomas and hyperplastic polyps in women.
Authors: Leitzmann MF,  Flood A,  Ferrucci LM,  Schoenfeld P,  Cash B,  Schatzkin A,  Cross AJ
Journal: Cancer Causes Control
Date: 2009 Oct
Branches: MEB
PubMed ID: 19387851
PMC ID: PMC3170996
Abstract: OBJECTIVE: To examine whether BMI is independently related to colorectal adenomas and hyperplastic polyps. METHODS: We conducted a cross-sectional study among 1,420 asymptomatic women aged 40-79 years who had undergone complete colonoscopy. Logistic regression was used to estimate the odds ratios (OR) and the corresponding 95% confidence intervals (CI) of adenomas and hyperplastic polyps. RESULTS: We identified 953 women (67.1%) with no polyps, 292 (20.6%) with adenomas, and 175 (12.3%) with hyperplastic polyps. Among those with polyps, 75 women (5.3% of total women) were classified as having both adenomas and hyperplastic polyps. After adjusting for potential risk factors for colorectal cancer, BMI was related to increased risk of adenomas (OR comparing obese to normal weight women = 1.57; 95% CI = 1.07-2.29). Further, BMI was associated with enhanced risk of hyperplastic polyps (OR = 3.76; 95% CI = 2.35-6.01) and the combination of adenomas and hyperplastic polyps (OR = 2.84; 95% CI = 1.41-5.72). CONCLUSIONS: Excess body mass is positively related to colorectal adenomas and hyperplastic polyps, particularly when both kinds of polyps are present in combination. Future studies should continue to delineate the possible differences in potential risk factors between colorectal adenomas and hyperplastic polyps. Such work should help further elucidate the possible causes of colorectal cancer.