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Title: Feasibility study of a human papillomavirus E6 oncoprotein test for diagnosis of cervical precancer and cancer.
Authors: Schweizer J,  Lu PS,  Mahoney CW,  Berard-Bergery M,  Ho M,  Ramasamy V,  Silver JE,  Bisht A,  Labiad Y,  Peck RB,  Lim J,  Jeronimo J,  Howard R,  Gravitt PE,  Castle PE
Journal: J Clin Microbiol
Date: 2010 Dec
Branches: HREB
PubMed ID: 20926711
PMC ID: PMC3008434
Abstract: In a feasibility study using a prototype, lateral-flow test for human papillomavirus type 16, 18, and/or 45 (HPV16/18/45) E6 oncoproteins, 51 of 75 (68%; 95% confidence interval [95% CI] of 56 to 78%) of HPV16/18/45 DNA-positive specimens from women with a diagnosis of CIN3+ (cervical intraepithelial neoplasia grade 3+ or cervical cancer) tested positive for HPV16/18/45 E6 oncoprotein. None of 16 (95% CI of 0 to 37%) HPV16/18/45 DNA-positive cervical specimens from women with a negative or CIN1 diagnosis tested positive for HPV16/18/45 E6 oncoprotein.