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Title: A genome-wide association study identifies a new ovarian cancer susceptibility locus on 9p22.2.
Authors: Song H,  Ramus SJ,  Tyrer J,  Bolton KL,  Gentry-Maharaj A,  Wozniak E,  Anton-Culver H,  Chang-Claude J,  Cramer DW,  DiCioccio R,  Dörk T,  Goode EL,  Goodman MT,  Schildkraut JM,  Sellers T,  Baglietto L,  Beckmann MW,  Beesley J,  Blaakaer J,  Carney ME,  Chanock S,  Chen Z,  Cunningham JM,  Dicks E,  Doherty JA,  Dürst M,  Ekici AB,  Fenstermacher D,  Fridley BL,  Giles G,  Gore ME,  De Vivo I,  Hillemanns P,  Hogdall C,  Hogdall E,  Iversen ES,  Jacobs IJ,  Jakubowska A,  Li D,  Lissowska J,  Lubiński J,  Lurie G,  McGuire V,  McLaughlin J,  Medrek K,  Moorman PG,  Moysich K,  Narod S,  Phelan C,  Pye C,  Risch H,  Runnebaum IB,  Severi G,  Southey M,  Stram DO,  Thiel FC,  Terry KL,  Tsai YY,  Tworoger SS,  Van Den Berg DJ,  Vierkant RA,  Wang-Gohrke S,  Webb PM,  Wilkens LR,  Wu AH,  Yang H,  Brewster W,  Ziogas A,  Australian Cancer (Ovarian) Study,  Australian Ovarian Cancer Study Group,  Ovarian Cancer Association Consortium,  Houlston R,  Tomlinson I,  Whittemore AS,  Rossing MA,  Ponder BA,  Pearce CL,  Ness RB,  Menon U,  Kjaer SK,  Gronwald J,  Garcia-Closas M,  Fasching PA,  Easton DF,  Chenevix-Trench G,  Berchuck A,  Pharoah PD,  Gayther SA
Journal: Nat Genet
Date: 2009 Sep
Branches: HREB
PubMed ID: 19648919
PMC ID: PMC2844110
Abstract: Epithelial ovarian cancer has a major heritable component, but the known susceptibility genes explain less than half the excess familial risk. We performed a genome-wide association study (GWAS) to identify common ovarian cancer susceptibility alleles. We evaluated 507,094 SNPs genotyped in 1,817 cases and 2,353 controls from the UK and approximately 2 million imputed SNPs. We genotyped the 22,790 top ranked SNPs in 4,274 cases and 4,809 controls of European ancestry from Europe, USA and Australia. We identified 12 SNPs at 9p22 associated with disease risk (P < 10(-8)). The most significant SNP (rs3814113; P = 2.5 x 10(-17)) was genotyped in a further 2,670 ovarian cancer cases and 4,668 controls, confirming its association (combined data odds ratio (OR) = 0.82, 95% confidence interval (CI) 0.79-0.86, P(trend) = 5.1 x 10(-19)). The association differs by histological subtype, being strongest for serous ovarian cancers (OR 0.77, 95% CI 0.73-0.81, P(trend) = 4.1 x 10(-21)).