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Title: Genetic basis for adverse events after smallpox vaccination.
Authors: Reif DM,  McKinney BA,  Motsinger AA,  Chanock SJ,  Edwards KM,  Rock MT,  Moore JH,  Crowe JE
Journal: J Infect Dis
Date: 2008 Jul 1
Branches: LTG, OD, CGR
PubMed ID: 18454680
PMC ID: PMC2746083
Abstract: Identifying genetic factors associated with the development of adverse events might allow screening before vaccinia virus administration. Two independent clinical trials of the smallpox vaccine (Aventis Pasteur) were conducted in healthy, vaccinia virus-naive adult volunteers. Volunteers were assessed repeatedly for local and systemic adverse events (AEs) associated with the receipt of vaccine and underwent genotyping for 1,442 singlenucleotide polymorphisms (SNPs). In the first study, 36 SNPs in 26 genes were associated with systemic AEs (P