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Title: Revisiting tissue specificity of germline cancer predisposing mutations.
Authors: Maris JM,  Knudson AG
Journal: Nat Rev Cancer
Date: 2015 Feb
Branches: HGP
PubMed ID:
PMC ID: not available
Abstract: Heritable germline mutations in major cancer genes generally lead to a restricted pattern of tissue-specific malignancies, yet many of the same mutations frequently occur somatically in a broad range of spontaneous neoplasms affecting different organs. Might this reflect a difference in tumorigenesis in children and adults?