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Title: Serum pepsinogens and risk of gastric and oesophageal cancers in the General Population Nutrition Intervention Trial cohort.
Authors: Ren JS,  Kamangar F,  Qiao YL,  Taylor PR,  Liang H,  Dawsey SM,  Liu B,  Fan JH,  Abnet CC
Journal: Gut
Date: 2009 May
Branches: NEB, GEB
PubMed ID: 19136509
PMC ID: PMC2792746
Abstract: OBJECTIVE: Low serum pepsinogen I (PGI) and low pepsinogen I/pepsinogen II ratio (PGI/II ratio) are markers of gastric fundic atrophy. We aimed to prospectively test the association between serum PGI/II ratio and risks of gastric non-cardia adenocarcinoma, gastric cardia adenocarcinoma, and oesophageal squamous cell carcinoma (OSCC). DESIGN: Case-cohort study nested in a prospective cohort with over 15 years of follow-up. SETTING: Rural region of the People's Republic of China. SUBJECTS: Men and women aged 40-69 years at study baseline. MAIN OUTCOME MEASURES: Adjusted hazard ratios and 95% confidence intervals for the association between serum PGI/II ratio and cancer risk. RESULTS: Compared to subjects with PGI/II ratio of >4, those with