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||SERUM LEVELS OF ORGANOCHLORINE COMPOUNDS AND RISK OF TESTICULAR GERM CELL TUMORS in: Abstracts of the 41st Annual Meeting of the Society for Epidemiologic Research
||Purdue MP, Engel LS, Anderson A, Langseth H, Needham LL, Barr DB, Blair A, Rothman N, McGlynn KA
||Am J Epidemiol
||2008 Jun 1
||There is speculation that exposure to organochlorine pollutants may increaserisk of testicular germ cell tumors (TGCT). To date, one smallcase-control study has addressed this hypothesis; in that study, elevatedlevels of polychlorinated biphenyls (PCBs) and certain organochlorine insecticides,chlordanes in particular, were associated with increased TGCTrisk. To further investigate this question, we conducted a nested casecontrolstudy within the Norwegian Janus serum bank cohort. Incident casesof TGCT (N = 49) diagnosed through 1999 were identified through linkageto the Cancer Registry of Norway. Controls (N = 53) were matched to caseson region, blood draw date and age at blood draw. Measurements of 34 PCBcongeners and 11 organochlorine insecticide compounds were performed.An increased relative risk of TGCTwas observed for elevated lipid-adjustedserum levels of oxychlordane (tertile 2, odds ratio (OR) 2.8, 95% confidenceinterval (CI) 0.8-21.5; tertile 3, OR 4.2, 95% CI 0.8-21.5; P = 0.05),trans-nonachlordane (3.1, 0.9-11.4; 2.9, 0.9-10.1; P = 0.07) and all chlordanescombined (2.5, 0.8-7.5; 3.4, 1.0-11.7; P = 0.01). Total PCB levelswere not associated with risk, although associations were observed forcongeners 99 (2.5, 0.8-7.8; 2.3, 0.8-6.3; P = 0.04) and 167 (1.9, 0.5-6.9;3.4, 0.9-13.4; P = 0.02). Our study, the first prospective investigation ofserum organochlorine levels and TGCT reported to date, confirms earlierfindings suggesting that exposure to chlordanes, and possibly some PCBcongeners, may increase risk. Further research evaluating the biologic effectsof chlordanes and other suspected endocrine modulators within thetestis is warranted.