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Title: PRRC2A and BCL2L11 gene variants influence risk of non-Hodgkin lymphoma: results from the InterLymph consortium.
Authors: Nieters A,  Conde L,  Slager SL,  Brooks-Wilson A,  Morton L,  Skibola DR,  Novak AJ,  Riby J,  Ansell SM,  Halperin E,  Shanafelt TD,  Agana L,  Wang AH,  De Roos AJ,  Severson RK,  Cozen W,  Spinelli J,  Butterbach K,  Becker N,  de Sanjose S,  Benavente Y,  Cocco P,  Staines A,  Maynadié M,  Foretova L,  Boffetta P,  Brennan P,  Lan Q,  Zhang Y,  Zheng T,  Purdue M,  Armstrong B,  Kricker A,  Vajdic CM,  Grulich A,  Smith MT,  Bracci PM,  Chanock SJ,  Hartge P,  Cerhan JR,  Wang SS,  Rothman N,  Skibola CF
Journal: Blood
Date: 2012 Nov 29
Branches: CGR, EBP, LTG, OEEB, REB
PubMed ID: 23047821
PMC ID: PMC3512239
Abstract: Many common genetic variants have been associated with non-Hodgkin lymphoma (NHL), but individual study results are often conflicting. To confirm the role of putative risk alleles in B-cell NHL etiology, we performed a validation genotyping study of 67 candidate single nucleotide polymorphisms within InterLymph, a large international consortium of NHL case-control studies. A meta-analysis was performed on data from 5633 B-cell NHL cases and 7034 controls from 8 InterLymph studies. rs3789068 in the proapoptotic BCL2L11 gene was associated with an increased risk for B-cell NHL (odds ratio = 1.21, P random = 2.21 × 10(-11)), with similar risk estimates for common B-cell subtypes. PRRC2A rs3132453 in the HLA complex class III region conferred a reduced risk of B-cell NHL (odds ratio = 0.68, P random = 1.07 × 10(-9)) and was likewise evident for common B-cell subtypes. These results are consistent with the known biology of NHL and provide insights into shared pathogenic components, including apoptosis and immune regulation, for the major B-cell lymphoma subtypes.