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Title: Maximizing resources to study an uncommon cancer: E2C2--Epidemiology of Endometrial Cancer Consortium.
Authors: Olson SH,  Chen C,  De Vivo I,  Doherty JA,  Hartmuller V,  Horn-Ross PL,  Lacey JV,  Lynch SM,  Sansbury L,  Setiawan VW,  Schouten LJ,  Shu XO
Journal: Cancer Causes Control
Date: 2009 May
Branches: HREB
PubMed ID: 19132539
PMC ID: PMC2868317
Abstract: Endometrial cancer affects more than 40,000 women a year in the U.S. While the association of this disease with high body mass index and sex steroid hormones is well known, there are many questions about etiology that have not been resolved. Little is known about the genetic basis for risk associated with hormones or obesity, other common genetic factors associated with risk, or gene-environment interactions. E2C2, the Epidemiology of Endometrial Cancer Consortium, was formed in 2006 to provide a collaborative environment for addressing these questions by pooling data from existing studies. This allows for investigations of uncommon risk factors, risk for rare histologic subtypes, and associations within strata that cannot be achieved in individual studies. This report describes the establishment of the consortium, ongoing projects that demonstrate the advantages of collaborative efforts, and challenges faced. Overall, the consortium promises to provide an important means of furthering our knowledge about this cancer.