Skip to Content
Discovering the causes of cancer and the means of prevention

Publications Search - Abstract View

Title: SELECT: the next prostate cancer prevention trial. Selenum and Vitamin E Cancer Prevention Trial.
Authors: Klein EA,  Thompson IM,  Lippman SM,  Goodman PJ,  Albanes D,  Taylor PR,  Coltman C
Journal: J Urol
Date: 2001 Oct
Branches: MEB, GEB
PubMed ID: 11547064
PMC ID: not available
Abstract: PURPOSE: Growing evidence implies that selenium and vitamin E may decrease the risk of prostate cancer. The Selenium and Vitamin E Cancer Prevention Trial (SELECT) is a randomized prospective double-blind study designed to determine whether selenium and vitamin E decrease the risk of prostate cancer in healthy men. MATERIALS AND METHODS: The preclinical and epidemiological evidence regarding chemoprevention with selenium and vitamin E were reviewed. Secondary analyses from randomized trials of the 2 agents were included in the current analysis. Data from these analyses as well as evidence from the Prostate Cancer Prevention Trial were used to develop the SELECT schema. RESULTS: Preclinical, epidemiological and phase III data imply that selenium and vitamin E have potential efficacy for prostate cancer prevention. The experience of the Prostate Cancer Prevention Trial shows the interest and dedication of healthy men to long-term studies of cancer prevention. A total of 32,400 men are planned to be randomized in SELECT. CONCLUSIONS: SELECT is the second large-scale study of chemoprevention for prostate cancer. Enrollment in the study is planned to begin in 2001 with final results anticipated in 2013.