Publications Search - Abstract View
| Title: |
Human papillomavirus and cervical cancer: biomarkers for improved prevention efforts. |
| Authors: |
Sahasrabuddhe VV, Luhn P, Wentzensen N |
| Journal: |
Future Microbiol |
| Date: |
2011 Sep |
| Branches: |
HREB |
| PubMed ID: |
21958146 |
| PMC ID: |
not available |
| Abstract: |
While organized screening programs in industrialized countries have significantly reduced cervical cancer incidence, cytology-based screening has several limitations. Equivocal or mildly abnormal Pap tests require costly retesting or diagnostic work-up by colposcopy and biopsy. In low-resource countries, it has been difficult to establish and sustain cytology-based programs. Advances in understanding human papillomavirus biology and the natural history of human papillomavirus-related precancers and cancers have led to the discovery of a range of novel biomarkers in the past decade. In this article, we will discuss the potential role of new biomarkers for primary screening, triage and diagnosis in high-resource countries and their promise for prevention efforts in resource constrained settings. |