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||FAMILY CANCER HISTORY, ADOLESCENT EXPOSURES, AND RISK OF COLORECTAL CANCER IN A PROSPECTIVE COHORT OF CHINESE WOMEN in: Abstracts of the 41st Annual Meeting of the Society for Epidemiologic Research
||Murphy G, Shu XO, Gao Y-T, Ji B-T, Cook M, Yang G, Li H-L, Rothman N, Zheng W, Chow W-H
||Am J Epidemiol
||2008 Jun 1
||BB, GEB, HREB, IIB, NEB, OEEB
||Sporadic colorectal cancer (CRC) in first degree relatives has been associatedwith a risk approximately twofold that of individuals without a familyhistory. Familial clustering may also be a result of shared environment. Weaimed to examine CRC risk in relation to a family history of cancer, and toevaluate whether family history-related risk may be explained by early lifeexposures. We followed 73,366 women in the Shanghai Women's HealthStudy for cancer incidence until December 2005. After an average of 7years of follow-up, 391 women were diagnosed with colorectal cancer. Wecalculated hazard ratios (HR) and 95% confidence intervals (CI) using Coxproportional hazards models adjusted for age, smoking, family income,education and body mass index (BMI). We observed a significant associationbetween CRC risk and family history of a parent being diagnosed withCRC (HR: 3.34; 95% CI: 1.58, 7.06). Daily or weekly red meat intakeduring adolescence was also significantly associated with risk of developingCRC as an adult (HR: 2.18; 95% CI: 1.23, 3.87). In contrast, we observedno association with adolescent BMI or physical exercise habits. Our resultssupport the hypothesis that family history of CRC is associated with anincreased risk of CRC. Possible links between diet, BMI and/or physicalactivity as an adolescent may warrant further investigation.