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Title: Genetic variation at chromosome 8q24 in osteosarcoma cases and controls.
Authors: Mirabello L,  Berndt SI,  Seratti GF,  Burdett L,  Yeager M,  Chowdhury S,  Teshome K,  Uzoka A,  Douglass C,  Hayes RB,  Hoover RN,  Savage SA,  National Osteosarcoma Etiology Study Group
Journal: Carcinogenesis
Date: 2010 Aug
Branches: OEEB, CGB, EBP, CGR
PubMed ID: 20530236
PMC ID: PMC2915635
Abstract: Osteosarcoma is a primary bone malignancy that typically occurs during the pubertal growth spurt. Only a few small association studies have evaluated common germ line variation in individuals with osteosarcoma. The 8q24 chromosomal region contains several loci that are associated with risk of many different cancers. We conducted an association study of common single-nucleotide polymorphisms (SNPs) across 8q24 to explore the role this region may play in osteosarcoma risk. We genotyped 214 tag SNPs in 99 osteosarcoma cases and 1430 controls (65 controls from a hospital-based case-control study and 1365 controls from a population-based study). Additive, dominant and recessive genetic models were evaluated using unconditional logistic regression to estimate odds ratios (ORs) and 95% confidence intervals (CIs). Analyses of nine SNPs previously associated with cancer did not show strong statistically significant associations. Of the remaining 205 SNPs, 7 were statistically significant (P