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Title: Chromosome translocations in workers exposed to benzene.
Authors: McHale CM,  Lan Q,  Corso C,  Li G,  Zhang L,  Vermeulen R,  Curry JD,  Shen M,  Turakulov R,  Higuchi R,  Germer S,  Yin S,  Rothman N,  Smith MT
Journal: J Natl Cancer Inst Monogr
Date: 2008
Branches: OEEB
PubMed ID: 18648008
PMC ID: not available
Abstract: As benzene has been linked with elevated risk of both acute myeloid leukemia and lymphoma, we explored the effect of benzene exposure on levels of t(8;21), t(15;17), and t(14;18) translocations. Circulating lymphocytes of normal individuals also often contain t(14;18). Quantitative polymerase chain reaction analysis showed that 37 workers with benzene exposure had a decreased level of t(14;18) in their blood with only 16.2% having 10 or more copies of the t(14;18) BCL-2/IgH fusion gene/microg DNA, as opposed to 55% of 20 controls (P = .0063 by Fisher's exact test). This decline may be related to the immunotoxicity to specific subtypes of circulating B-lymphocytes, but the data do not support the use of t(14;18) as a biomarker of increased lymphoma risk in benzene-exposed populations. None of 88 individuals (31 controls and 57 exposed) exhibited detectable t(8;21) transcripts, and while t(15;17) transcripts were detected in two individuals, the result is inconclusive as one was exposed and the other was unexposed.