Skip to Content
Discovering the causes of cancer and the means of prevention

Publications Search - Abstract View

Title: Therapeutic radiation and the potential risk of second malignancies.
Authors: Kamran SC,  Berrington de Gonzalez A,  Ng A,  Haas-Kogan D,  Viswanathan AN
Journal: Cancer
Date: 2016 Jun 15
Branches: REB
PubMed ID: 26950597
PMC ID: not available
Abstract: Radiation has long been associated with carcinogenesis. Nevertheless, it is an important part of multimodality therapy for many malignancies. It is critical to assess the risk of secondary malignant neoplasms (SMNs) after radiation treatment. The authors reviewed the literature with a focus on radiation and associated SMNs for primary hematologic, breast, gynecologic, and pediatric tumors. Radiation appeared to increase the risk of SMN in all of these; however, this risk was found to be associated with age, hormonal influences, chemotherapy use, environmental influences, genetic predisposition, infection, and immunosuppression. The risk also appears to be altered with modern radiotherapy techniques. Practitioners of all specialties who treat cancer survivors in follow-up should be aware of this potential risk. Cancer 2016;122:1809-21. 2016 American Cancer Society.