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Title: Estrogen receptor beta rs1271572 polymorphism and invasive ovarian carcinoma risk: pooled analysis within the Ovarian Cancer Association Consortium.
Authors: Lurie G,  Wilkens LR,  Thompson PJ,  Shvetsov YB,  Matsuno RK,  Carney ME,  Palmieri RT,  Wu AH,  Pike MC,  Pearce CL,  Menon U,  Gentry-Maharaj A,  Gayther SA,  Ramus SJ,  Whittemore AS,  McGuire V,  Sieh W,  Pharoah PD,  Song H,  Gronwald J,  Jakubowska A,  Cybulski C,  Lubinski J,  Schildkraut JM,  Berchuck A,  Krüger Kjær S,  Høgdall E,  Fasching PA,  Beckmann MW,  Ekici AB,  Hein A,  Chenevix-Trench G,  Webb PM,  Beesley J,  Australian Ovarian Cancer Study Group,  Australian Cancer Study Group,  Goodman MT,  Ovarian Cancer Association Consortium,  Bowtell D,  Chenevix-Trench G,  deFazio A,  Gertig D,  Green A,  Webb PM,  Green A,  Parsons P,  Hayward N,  Webb PM,  Whiteman D,  Chenevix-Trench G,  Johnatty SE,  Beesley J,  Chen X,  Webb PM,  Pike MC,  Wu AH,  Pearce CL,  Edlund CK,  Van den Berg DJ,  Gayther SA,  Ramus SR,  Fasching PA,  Garcia-Closas M,  Yang HP,  Chanock S,  Wentzensen N,  Brinton LA,  Anton-Culver H,  Ziogas A,  Brewster W,  Goode EL,  Fridley BL,  Vierkant RA,  Cunningham JM,  Berchuck A,  Schildkraut JM,  Iversen ES Jr,  Moorman PG,  Palmieri RT,  Goodman MT,  Carney ME,  Thompson PJ,  Wilkens LR,  Lurie G,  Cramer DW,  Gates MA,  De Vivo I,  Hankinson SE,  Tworoger SS,  Terry KL,  Doherty JA,  Cushing-Haugen KL,  Chen C,  Rossing MA,  Cook LS,  Moysich K,  DiCioccio R,  Grasela MT,  Ness RB,  Whittemore AS,  McGuire V,  Sieh W,  Lancaster JM,  Risch HA,  Hogdall C,  Hogdall E,  Kruger Kjaer S,  Butzow R,  Gentry-Maharaj A,  Menon U,  Pharoah PD,  Perkins B,  Shah M,  Song H,  Kelemen LE,  Gronwald J,  Lubinski J,  Lissowska J,  Chang-Claude J,  Wang-Gohrke S
Journal: PLoS One
Date: 2011
Branches: HREB, LTG, OD, OEEB
PubMed ID: 21673961
PMC ID: PMC3108970
Abstract: The association of ovarian carcinoma risk with the polymorphism rs1271572 in the estrogen receptor beta (ESR2) gene was examined in 4946 women with primary invasive ovarian carcinoma and 6582 controls in a pooled analysis of ten case-control studies within the Ovarian Cancer Association Consortium (OCAC). All participants were non-Hispanic white women. Odds ratios (ORs) and 95% confidence intervals (CIs) were estimated using unconditional logistic regression adjusted for site and age. Women with the TT genotype were at increased risk of ovarian carcinoma compared to carriers of the G allele (OR = 1.10; 95%; CI: 1.01-1.21; p = 0.04); the OR was 1.09 (CI: 0.99-1.20; p = 0.07) after excluding data from the center (Hawaii) that nominated this SNP for OCAC genotyping A stronger association of rs1271572 TT versus GT/GG with risk was observed among women aged ≤50 years versus older women (OR = 1.35; CI: 1.12-1.62; p = 0.002; p for interaction = 0.02) that remained statistically significant after excluding Hawaii data (OR = 1.34; CI: 1.11-1.61; p = 0.009). No heterogeneity of the association was observed by study, menopausal status, gravidity, parity, use of contraceptive or menopausal hormones, tumor histological type, or stage at diagnosis. This pooled analysis suggests that rs1271572 might influence the risk of ovarian cancer, in particular among younger women.