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Title: Genetic polymorphisms in cytochrome P450s, GSTs, NATs, alcohol consumption and risk of non-Hodgkin lymphoma.
Authors: Li Y,  Zheng T,  Kilfoy BA,  Lan Q,  Holford T,  Han X,  Zhao P,  Dai M,  Leaderer B,  Rothman N,  Zhang Y
Journal: Am J Hematol
Date: 2010 Mar
Branches: OEEB
PubMed ID: 20131310
PMC ID: PMC2965357
Abstract: The aim of this study was to investigate whether genetic polymorphisms in cytochrome P450s (CYPs), glutathione S-transferases (GSTs), and N-acetyltransferases (NATs) genes modify the relationship between alcohol consumption and risk of non-Hodgkin's lymphoma (NHL) in a population-based, case-control study including 1,115 Connecticut women. Although we did not find strong evidence that the genetic polymorphisms modify the relationship between alcohol consumption and risk of NHL, we identified significant interactions for multiple GSTs and NATs and alcohol intake among persons with DLBCL. Our results confer support investigation of the gene-environment interaction in a larger study population of DLBCL.