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Title: Association of body mass index and risk of death from pancreatic cancer in Asians: findings from the Asia Cohort Consortium.
Authors: Lin Y,  Fu R,  Grant E,  Chen Y,  Lee JE,  Gupta PC,  Ramadas K,  Inoue M,  Tsugane S,  Gao YT,  Tamakoshi A,  Shu XO,  Ozasa K,  Tsuji I,  Kakizaki M,  Tanaka H,  Chen CJ,  Yoo KY,  Ahn YO,  Ahsan H,  Pednekar MS,  Sauvaget C,  Sasazuki S,  Yang G,  Xiang YB,  Ohishi W,  Watanabe T,  Nishino Y,  Matsuo K,  You SL,  Park SK,  Kim DH,  Parvez F,  Rolland B,  McLerran D,  Sinha R,  Boffetta P,  Zheng W,  Thornquist M,  Feng Z,  Kang D,  Potter JD
Journal: Eur J Cancer Prev
Date: 2013 May
Branches: HREB, NEB, OEEB
PubMed ID: 23044748
PMC ID: PMC3838869
Abstract: We aimed to examine the association between BMI and the risk of death from pancreas cancer in a pooled analysis of data from the Asia Cohort Consortium. The data for this pooled analysis included 883 529 men and women from 16 cohort studies in Asian countries. Cox proportional-hazards models were used to estimate the hazard ratios and 95% confidence intervals for pancreas cancer mortality in relation to BMI. Seven predefined BMI categories (<18.5, 18.5-19.9, 20.0-22.4, 22.5-24.9, 25.0-27.4, 27.5-29.9, ≥ 30) were used in the analysis, with BMI of 22.5-24.9 serving as the reference group. The multivariable analyses were adjusted for known risk factors, including age, smoking, and a history of diabetes. We found no statistically significant overall association between each BMI category and the risk of death from pancreas cancer in all Asians, and obesity was unrelated to the risk of mortality in both East Asians and South Asians. Age, smoking, and a history of diabetes did not modify the association between BMI and the risk of death from pancreas cancer. In planned subgroup analyses among East Asians, an increased risk of death from pancreas cancer among those with a BMI less than 18.5 was observed for individuals with a history of diabetes; hazard ratio=2.01 (95% confidence interval: 1.01-4.00) (P for interaction=0.07). The data do not support an association between BMI and the risk of death from pancreas cancer in these Asian populations.