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Title: Breast cancer risk and 6q22.33: combined results from Breast Cancer Association Consortium and Consortium of Investigators on Modifiers of BRCA1/2.
Authors: Kirchhoff T,  Gaudet MM,  Antoniou AC,  McGuffog L,  Humphreys MK,  Dunning AM,  Bojesen SE,  Nordestgaard BG,  Flyger H,  Kang D,  Yoo KY,  Noh DY,  Ahn SH,  Dork T,  Schürmann P,  Karstens JH,  Hillemanns P,  Couch FJ,  Olson J,  Vachon C,  Wang X,  Cox A,  Brock I,  Elliott G,  Reed MW,  Burwinkel B,  Meindl A,  Brauch H,  Hamann U,  Ko YD,  GENICA Network,  Broeks A,  Schmidt MK,  Van 't Veer LJ,  Braaf LM,  Johnson N,  Fletcher O,  Gibson L,  Peto J,  Turnbull C,  Seal S,  Renwick A,  Rahman N,  Wu PE,  Yu JC,  Hsiung CN,  Shen CY,  Southey MC,  Hopper JL,  Hammet F,  Van Dorpe T,  Dieudonne AS,  Hatse S,  Lambrechts D,  Andrulis IL,  Bogdanova N,  Antonenkova N,  Rogov JI,  Prokofieva D,  Bermisheva M,  Khusnutdinova E,  van Asperen CJ,  Tollenaar RA,  Hooning MJ,  Devilee P,  Margolin S,  Lindblom A,  Milne RL,  Arias JI,  Zamora MP,  Benítez J,  Severi G,  Baglietto L,  Giles GG,  kConFab,  AOCS Study Group,  Spurdle AB,  Beesley J,  Chen X,  Holland H,  Healey S,  Wang-Gohrke S,  Chang-Claude J,  Mannermaa A,  Kosma VM,  Kauppinen J,  Kataja V,  Agnarsson BA,  Caligo MA,  Godwin AK,  Nevanlinna H,  Heikkinen T,  Fredericksen Z,  Lindor N,  Nathanson KL,  Domchek SM,  SWE-BRCA,  Loman N,  Karlsson P,  Stenmark Askmalm M,  Melin B,  von Wachenfeldt A,  HEBON,  Hogervorst FB,  Verheus M,  Rookus MA,  Seynaeve C,  Oldenburg RA,  Ligtenberg MJ,  Ausems MG,  Aalfs CM,  Gille HJ,  Wijnen JT,  Gómez García EB,  EMBRACE,  Peock S,  Cook M,  Oliver CT,  Frost D,  Luccarini C,  Pichert G,  Davidson R,  Chu C,  Eccles D,  Ong KR,  Cook J,  Douglas F,  Hodgson S,  Evans DG,  Eeles R,  Gold B,  Pharoah PD,  Offit K,  Chenevix-Trench G,  Easton DF,  BCAC/CIMBA
Journal: PLoS One
Date: 2012
Branches: HREB, IIB, NEB, OEEB
PubMed ID: 22768030
PMC ID: PMC3387216
Abstract: Recently, a locus on chromosome 6q22.33 (rs2180341) was reported to be associated with increased breast cancer risk in the Ashkenazi Jewish (AJ) population, and this association was also observed in populations of non-AJ European ancestry. In the present study, we performed a large replication analysis of rs2180341 using data from 31,428 invasive breast cancer cases and 34,700 controls collected from 25 studies in the Breast Cancer Association Consortium (BCAC). In addition, we evaluated whether rs2180341 modifies breast cancer risk in 3,361 BRCA1 and 2,020 BRCA2 carriers from 11 centers in the Consortium of Investigators of Modifiers of BRCA1/2 (CIMBA). Based on the BCAC data from women of European ancestry, we found evidence for a weak association with breast cancer risk for rs2180341 (per-allele odds ratio (OR) = 1.03, 95% CI 1.00-1.06, p = 0.023). There was evidence for heterogeneity in the ORs among studies (I(2) = 49.3%; p = <0.004). In CIMBA, we observed an inverse association with the minor allele of rs2180341 and breast cancer risk in BRCA1 mutation carriers (per-allele OR = 0.89, 95%CI 0.80-1.00, p = 0.048), indicating a potential protective effect of this allele. These data suggest that that 6q22.33 confers a weak effect on breast cancer risk.